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Porcine Reproductive and Respiratory Syndrome virus (PRRSv) continues to cause critical issues for the swine industry worldwide, with an estimated loss of $1billion annually in the United States. PRRSv is a genetically diverse RNA Arterivirus with up to 20% variability. Available vaccines, mainly modified-live and autogenous, provide limited protection against divergent strains. Additionally, PRRSv immune dysregulation, and immune evasion strategies pose huge challenges in the successful development of cross-protective vaccines. A vital immune evasion strategy utilized is termed deceptive imprinting. Many pathogens contain highly immunodominant, commonly variable, non-protective or partially protective antigenic determinants termed “decoys”. Decoys subvert host immune responses away from conserved, cross protective and critical viral determinants leading to poor vaccine performance. In attempt to subvert immunodominance of decoys, by masking decoys with PRRSv specific antibodies, we hypothesize virus-antibody complex vaccine can improve vaccine performance. We present efficacy of preliminary and primary vaccine trials utilizing antibodyvirus complex (Ab-virus) vaccines in prevention of homologous and heterologous PRRSv infection through assessment of viral loads as determined by real-time polymerase chain reaction and PRRSv associated pathology in the lung. Additionally, we determined the safety and immunogenicity of the Ab-virus complex. Antibody-virus complex vaccines were compared to autogenous and commercially available PRRSv vaccines. An initial study utilizing Ab-virus complex vaccine and heterologous

Prevention of heterologous Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection using an antibody-virus complex vaccine