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v CHAPTER I. GENERAL INTRODUCTION 1 Dissertation organization 1 Literature Review I: Non-invasive imaging of the optic nerve 2 Literature Review II: Parkinson’s disease – more than just a motor disorder 5 Literature Review III: Blast exposure and traumatic brain injury 11 CHAPTER II. CHARACTERIZATION OF STRUCTURE AND FUNCTION OF THE MOUSE RETINA USING PATTERN ELECTRORETINOGRAPHY, PUPIL LIGHT REFLEX AND OPTICAL COHERENCE TOMOGRAPHY 18 Abstract 1818 Introduction 19 Materials and Methods 20 Results 24 Discussion 26 Acknowledgements 30 Figures30 Figure Legends34 CHAPTER III. PROTEIN KINASE C DELTA MEDIATES RETINAL GANGLION CELL FUNCTION LOSS FOLLOWING MPTP TREATMENT IN MICE37 Abstract 3737

Assessment of optic neuropathy as a result of direct and indirect injury using non- invasive functional and structural analytical tools