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This study aimed to determine the relationship of thyroid hormone disturbance and prolactin over production to impact on the menstrual irregularities anovulation .This study were carried out in Al-Karama teaching hospital and included (47) primary infertile women, (30 ) of them were with hypothyroidism , the patients aged between (18-40). This study extended from February to June 2017. The hormonal assay of TSH, FT3, FT4 ,FSH , LH and PRL that revealed :There were high significantly (p < 0.01) increased in TSH concentrations , significantly (p < 0.05) decreased in levels of FT3 and FT4. Gonadotropins hormones recorded significantly ( p <0.05) decreased in levels of FSH and non significantly increased in levels of LH. Prolactin concentrations that obtained revealed to significantly (p < 0.05) increased in patients with hypothyroidism . This study reported there were (70%) of hypothyroidism patients with menstrual disturbance. We concluded , that hypothyroidism and Hyperprolactinemia commonly related and synergized to menstrual irregularities and ovulatory failure. Key word: Infertile , anovulation , hypothyroidism, Hyperprolactinemia

Synergism of Hypothyroidism and Hyperprolactinemia to impact on efficiency of menstrual cycle and ovulatory status