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Long-term clinical observations show that widely used dentures made of metals and their alloys are not indifferent, cause a number of diseases of the oral mucosa, and have social and medical consequences in the form of intolerance to dental prosthesis materials[1,2]. Currently, ceramic materials, plastics, stainless steels, cobaltchromium, silver-palladium alloys, gold-based alloys, platinum, etc. are used for orthopedic treatment. these alloys include the following metals: iron, chromium, Nickel, titanium, manganese, silicon, molybdenum, cobalt, palladium, zinc, silver, gold, etc. Signs of intolerance may occur when placing dentures and filling materials in the oral cavity. Intolerance to prosthetic materials can be caused by different reasons that have different mechanisms of pathology development. Solving problems with intolerance to dental materials in each patient requires analysis together with a dentist, an immunologist, and an immunological laboratory [1-4].

Due to intolerance of dental materials used for therapeutic treatment