Open AccessPreparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation
Author(s) -
Ida Rasmusson Duprez,
Ulrika Johansson,
Bo Nilsson,
Olle Korsgren,
Peetra U. Magnusson
Publication year - 2010
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2010.524320
Subject(s) - medicine , islet , mesenchymal stem cell , transplantation , islet cell transplantation , microbiology and biotechnology , pathology , insulin , biology
Low engraftment and adverse immune reactions hamper the success rate of clinical islet transplantation. In this study, we investigated the capacity of human mesenchymal stem cells (MSCs) to adhere to human islets of Langerhans and their effects in immune modulation and during blood interactions in vitro.