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Inhibition of α- amylase play a vital role in the clinical management of postprandial hyperglycemia. Although, powerful synthetic inhibitors are available, natural inhibitors are potentially safer.The present study was carried out to evaluate α- amylase inhibition activity from hydroalcoholic extracts from aerial parts of Cestrum nocturnum. Hydroalcoholic extract was prepared by Soxhletation Method. The extract showed strong inhibition towards α- amylase activity and IC50 value were 45.9 μg. This In vitro studies indicate the potential of C. nocturnum in the development of effective anti-diabetic agents.

Inhibitory effect of hydroalcoholic extract of Cestrum Nocturnum on α-amylase activity