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Vitiligo is the most common acquired depigmentation of the skin, affecting the patient's self- image and negatively affecting quality of life. As for the pathogenesis of vitiligo, there is an autoimmune theory. Vitamin D deficiency has been shown to exist in many autoimmune diseases. Vitamin D is an essential hormone with pleiotropic effects, especially anti-apoptosis and regulatory functions of melanocyte proliferation and differentiation. It has been hypothesized that it may play a supportive role in the repigmentation of white matter lesions. The immunomodulatory activity of vitamin D may be used to treat vitiligo.

Serum Vitamin D concentrations and their association with the clinical severity of vitiligo