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Suzuki cross coupling reaction is one of the most famous organic reactions of the 20th century’s chemistry. It is deemed of as one of the most famous reaction in the field of chemistry. It is a very effective method for making carbon–carbon bonds. It has been extensively utilized in the synthesis of many carbon molecules including the most complex ones.Syntheses of 2-diethylamino-4H-7-(Het) aryl pyrido [1,2-a] [1,3,5] triazin-4-ones are currently under investigation in order to obtain great potentialities in medicinal chemistry of compounds class. The methodology we propose herein is able to produce numerous 2-diethylamino-4H-7-(Het)arylpyrido[1,2-a][1,3,5]triazin-4-one and derivatives that were synthesized, purified and characterized by 1HNMR, 13CNMR, MS techniques. Furthermore, it allows sequential introduction of various substituents into a 2-alkylylamino-4H-7-(Het)arylpyrido[1,2-a][1,3,5]triazin-4-ones ring using a one-pot procedure. The biological evaluation as well as the physico-chemical characterisation of various products are currently under way and will be described elsewhere.

world journal of advanced research and reviews

Synthesis of Novel 2-diethylamino-4H-7-(Het) aryl pyrido[1,2-a][1,3,5]triazin-4-ones via a Suzuki Cross-Coupling Reaction of 2-Diethylamino-4H-7-iodopyrido[1,2a][1,3,5]triazin-4-one with (Het) arylboronic Acids in Water