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Background: The presence of cell or tissue damage always followed byinflammatory reactions. Inflammatory process should not persist because it can interfere even inhibit regeneration. An increased circulation of IL-1, IL-6 and TNF-alpha happens in chronic inflammation. IL-1 is granulocytes chemoattractant and has function to localize inflammation. Overexpression of IL-1 can inhibit wound healing so it needs currative treatment to decrease IL-1’s expression. Purpose: To know expression of IL-1 after provision of Clariasbatrachus fish oil. Methods: We have used the post test only design in this research. There have been 19 Rattusnovergicus as research samples and those were divided into 3 groups, group 1 as control, group 2 has given 10% fish oil and group 2 has given 5% fish oil. Chronic inflammation treated to all samples for three days. The group 1 and 2 given Clariasbatrachusfish oil on the third day. We did decapitation on the fourth day to perform Immunohistochemistrystaining. The data were tabulated and analyzed statistically used Oneway ANOVA. Result: Group 2 and 3 has lower IL-1 expression than Control group.There is significant difference between groups. Conclusion: Clariasbatrachus Fish oil can lowered IL-1 expression onmucosal cavity’s chronic inflammation.

Expression of IL-1 on Mucosal Cavity's Chronic Inflammation after Provision of Clarias Batrachus Fish Oil