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Background: Propionibacterium acnes includes gram-positive bacteria in the form of stems and normal skin flora that play a role in the occurrence of inflammation in acne. The prevalence of acne ranges from 47-90% during adolescence. African, American and Hispanic women have a prevalence of 37% and 32% while Asian women are 30%, Caucasian 24%, and India 23%. Leaves melinjo contain flavonoid compounds that function as antioxidants that will interfere with the metabolic functions of microorganisms such as bacteria. Purpose: This study aims to determine the effectiveness of melinjo leaf extract (Gnetum gnemon L) on the growth of bacteria Propionibacterium acnes, using design Descriptive. Data analysis using univariate analysis to know effectivity of leaf extract of melinjo to the growth of bacterium Propionibacterium acnes. Method: This study used melinjo leaf extract which was generated using 96% ethanol solvent. Results: The study showed that concentrations that could inhibit the growth of bacteria Propionibacterium acnes were at concentrations of 2.5%, 5%, 7.5%, and 10%. Inhibition zone diameter at 2.5% concentration of 6.13 mm, 5% concentration of 6.68 mm, 7.5% concentration of 7.92 mm and 10% concentration of 10.94 mm. It means the higher concentration of melinjo leaf extract hence the higher the resistance of bacteria Propionibacterium acnes. Conclusion: Further research is expected to carry out further tests with other concentrations and solvent extracts other than 96% ethanol or bacteria other than Propionibacterium acnes.

Test Effectiveness Antimicrobial Extract Etanol Leaves Melinjo (Gnetum gnemon L.) On Growth Of Bacteria Propionibacterium Acnes