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21st century education produces culture for the principals of teachers, students and the environment to integrate technology, pedagogy, and content mastery (TPACK) into a single entity. One way to achieve learning goals that are in line with 21st century learning that is also a form of industrial revolution 4.0 is laboratory-based learning and integration of IT use in science learning. The purpose of this research is to find out the best formulation in the use of technology that can be considered in laboratory-based learning. Many options to implement the application of technology in laboratory-based learning including virtual lab, remote lab and MBL. This study used the Systematic Literature Review (SLR) method. It is used in this article will illustrate the advantages and disadvantages of each type of technology commonly used in science-based laboratory learning in the world. Therefore, the role of teacher / educator is important to design and select the right technology in building learners' knowledge. Based on the results of each analysis Technology (virtual lab, remote lab and MBL) is not perfect, it needs modification in order that the learning objectives, the use of technology and the local conditions can work optimally. Educators need to emphasize that what is more important is that learning activities are not located within the mastery of computer technology but in their educational practices. Keywords—laboratory, science, TPACK.

Tpack as Innovation of Learning Science Laboratory of Indonesia