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Keywords solid lipid nanoparticles; Chrysin; Cytotoxicity; Antitumor activity; H22 cells; tumor bearing mice Abstract Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Chrysin (Chr), a major symbol ingredient in Chinese Propolis, has a wide range of pharmacologic al properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Chr-loaded solid lipid nanoparticles (Chr-SLN) composed of Chr, cremophor EL and glyceryl behenate were prepared by high pressure homogenization technique. The in vivo anti-hepatocarcinoma effects of Chr-SLN relative to efficacy of bulk Chr were evaluated. The particle size and zeta potential of Chr-SLN were 479.7 nm and −26.3 mV, respectively. The results showed higher antitumor efficacy against H22 solid tumor bearing mice. These results suggest that the delivery of Chr-SLN is a promising approach for treating tumors.

Anti-hepatocarcinoma effects of chrysin loaded solid lipid nanoparticle against H22 tumor bearing mice