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Ricinoleic acid (RA) is a type of fatty acid found in castor oil and has been known to have anti-inflammatory effects Phospholipids are useful functional compounds in food/medical fields due to their amphiphilic property and biocompatibility. The purpose of this study was to prepare phospholipid containing RA and to evaluate the compound’s antiinflammatory activity in vitro. Lyso-phosphatidylcholine (LPC) from egg yolk was subjected to phospholipase A2-mediated esterification for the preparation of phosphatidylcholine containing RA (RA-PC). The prepared RA-PC was then evaluated for its anti-inflammatory activity against the murine macrophage-like cell line RAW264.7. Using glycerol as solvent and formamide as water mimic, RA-PC was successfully prepared. Upon optimizing the molar ratio (RA/LPC), the amount of glycerol, and the reaction time, a maximum yield of 57.5 mol% was obtained. A dose dependent decrease in the expression levels of IL-6 and IL-1β was observed upon addition of RA-PC into the culture medium of RAW264.7. Down regulation of gene expression was higher for RA-PC than for RA or Soy-PC, which suggests that the anti-inflammatory effects of RA were improved following phosphatidylation. Our data suggest that RA-PC is a potential compound for use as an antiinflammatory agent. Keywords—anti-inflammatory, phospholipase A2, ricinoleic acid

Phospholipase A2-Mediated Preparation of Phosphatidylcholine Containing Ricinoleic Acid And Its Anti-Inflammatory Effect in Vitro