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This article describes the results of the authors’ experimental studies of pathomorphological changes in laboratory animals associated with intoxication with nitrosocontaining (clothianidin) and cyano-containing (thiacloprid) compounds from the group of neonicotinoids. Acute intoxication was caused in 20 white outbred rats by single intragastric, via the tube, administration of pesticides Calypso (active ingredient thiacloprid, 480 g/L, BayerCropSciense, Germany) and AnoEx (active ingredient clotianidin, 20 g/L, Agravis Raiffeisen AG, Germany) in the doses of 1/10 LD50, respectively. Control group included intact animals (n=10). To assess the overall morphological picture, histological sections were stained with hematoxylin and eosin, and Perls’ method was used to indicate hemosiderin. Microphotography of histological preparations was carried out using Altami BIO 1 microscope with USMOSO3100KPA USB digital ocular camera. The research results prove that neonicotinoids, despite differences in their chemical structure (nitrosoand cyanocontaining preparations), cause the development of multiple organ pathologies due to vascular disorders. As a result of damaged microvasculature and endothelium of large vessels, the breakdown of histochematic barrier occurs what contributes to the delivery of pesticides and their metabolites into the cells of organs and damage of these organs. In addition, vascular disorders lead to the development of hypoxia which exacerbates the damaging effect on vascular wall and tissues. Dystrophic changes and multiple hemorrhages develop in parenchymal organs, and fibrillogenesis is activated. In some cases, there are alternative changes in the form of focal necrosis of liver. Expanded spleen marginal zone and increased area of periarteriolar lymphoid sheaths reveal immunity stress and potential danger of immunosuppression in the postintoxication period. Mentioned pathomorphological changes in the animal organism allow planning complex diagnostic and therapeutic measures in the course of the use of neonicotinoids. Keywords—neonicotinoids, thiacloprid, clothianidin, Calypso, AnoEx, acute intoxication, pathomorphological changes.

Pathomorphological Changes in the Organs and Tissues of Animals During Acute Intoxication with Neonicotinoids Containing Nitroso or Cyano Group