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Cardiovascular Disease (CVD) is a major cause of morbidity and mortality globally. Age-related elevated blood pressure and metabolic-related biochemical markers including cholesterol, triglyceride, and glucose, are considered important conventional risk factors of CVD risk [1–3]. But, these traditional risk factors only do not fully account for the development in CVD events [4]. In addition to well-established risk factors, mental health status and psychological well-being has been also recognized as an important risk factor for CVD as well as behavioral concern about unhealthy diet, physical activity, and obesity [5,6]. Negative mental health may increase adrenal hormones, sympathetic nerve activity, and endothelial dysfunction, which all contributes to cardiovascular abnormality [7,8]. Prospective cohort studies have revealed that depression is likely to increase risk for the onset of CVD events [9,10]. Similarly, the status of general mental health, measured by self-reported screening, is also found to be a predictor of CVD [6,11]. Then, the relationship between psychological stress and normal functioning of the cardiovascular system seems to be have clinical and research interests.

Association between Mental Health and Arterial Stiffness in Middle-aged and Older Adults