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Various genetic mouse models have been used to understand aspects of the biology of the neurodegenerative disease. A rapid growth of data collection from the mouse brain has put image registration, a key prerequisite step for brain image analysis in great focus. SyN (symmetric image normalization method) is one of the most performed diffeomorphic strategies which has been widely used in human brain mapping. In this study, we optimized the SyN strategy for tiny mouse brain. The optimized protocol is able to accurately remove the anatomical variability between mouse brain MR microscopy (MRM) and offers superior performance over the SyN protocol for human.

Symmetric image normalization for mouse brain magnetic resonance microscopy