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Our purpose was to identify correlations between 18 F-fluorodihydroxyphenylalanine ( 18 F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes and to evaluate their prognostic values. Methods: Sixty-eight treatment-naïve glioma patients who underwent 18 F-FDOPA PET and physiologic MRI were retrospectively selected (36 with isocitrate dehydrogenase wild-type [IDH wt ], 16 with mutant 1p/19q noncodeleted [IDH m-noncodel ], and 16 with mutant codeleted [IDH m-codel ]). Fluid-attenuated inversion recovery hyperintense areas were segmented and used as regions of interest. For voxelwise and patientwise analyses, Pearson correlation coefficients ( r  voxelwise and r  patientwise ) between the normalized SUV (nSUV), rCBV, and ADC were evaluated. Cox regression analysis was performed to investigate the associations between overall survival and r  voxelwise , maximum or median nSUV, median rCBV, or median ADC. Results: For IDH wt and IDH m-noncodel gliomas, nSUV demonstrated significant positive correlations with rCBV ( r  voxelwise = 0.25 and 0.31, respectively; r  patientwise = 0.50 and 0.70, respectively) and negative correlations with ADC ( r  voxelwise = -0.19 and -0.19, respectively; r  patientwise = -0.58 and -0.61, respectively) in both voxelwise and patientwise analyses. IDH m-codel gliomas demonstrated a significant positive correlation between nSUV and ADC only in voxelwise analysis ( r  voxelwise = 0.18). In Cox regression analysis, r  voxelwise between nSUV and rCBV (hazard ratio, 28.82) or ADC (hazard ratio, 0.085) had significant associations with overall survival for only IDH wt gliomas. Conclusion: IDH m-codel gliomas showed distinctive patterns of correlations between amino acid PET and physiologic MRI. Stronger correlations between nSUV and rCBV or ADC may result in a worse prognosis for IDH wt gliomas.

the journal of nuclear medicine

Voxelwise and Patientwise Correlation of <sup>18</sup>F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naïve Diffuse Gliomas with Different Molecular Subtypes

Voxelwise and Patientwise Correlation of 18F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naïve Diffuse Gliomas with Different Molecular Subtypes

Voxelwise and Patientwise Correlation of ¹⁸F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naïve Diffuse Gliomas with Different Molecular Subtypes