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Patient premedication with carbidopa seems to improve the accuracy of 6- 18 F-fluoro-3,4-dihydroxy-l-phenylalanine ( 18 F-FDOPA) PET for insulinoma diagnosis. However, the risk of PET false-negative results in the presence of carbidopa is a concern. Consequently, we aimed to evaluate the effect of carbidopa on 18 F-FDOPA uptake in insulinoma β-cells and an insulinoma xenograft model in mice.

Effect of Carbidopa on 18F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging

Effect of Carbidopa on ¹⁸F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging