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Accurate assessment of kidney function plays an essential role for optimal clinical decision making in a variety of diseases. The major intrinsic advantages of PET are superior spatial and temporal resolutions for quantitative tomographic renal imaging. 2-deoxy-2- 18 F-fluorodeoxysorbitol ( 18 F-FDS) is an analog of sorbitol that is reported to be freely filtered at the renal glomerulus without reabsorption at the tubule. Furthermore, it can be synthesized via simple reduction of widely available 18 F-FDG. We tested the feasibility of 18 F-FDS renal PET imaging in rats.

Initial Preclinical Evaluation of 18F-Fluorodeoxysorbitol PET as a Novel Functional Renal Imaging Agent

Initial Preclinical Evaluation of ¹⁸F-Fluorodeoxysorbitol PET as a Novel Functional Renal Imaging Agent