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(R)-[(11)C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely.

Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (R)-[11C]PK11195 in Traumatic Brain Injury

Reference Tissue Models and Blood–Brain Barrier Disruption: Lessons from (R)-[¹¹C]PK11195 in Traumatic Brain Injury