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Sepsis is a life-threatening condition that result in organ dysfunction and diagnosed with SOFA score. It is often accompanied by kidney disorders that inhibit uric acid excretion causing hyperuricemia. Objective: To determine the role of serum uric acid levels as predictors of sepsis severity associated with SOFA scores. Method: This is an analytic study conducted from JuneAugust 2019 on 38 sepsis patients at ICU Adam Malik Hospital Medan. Sepsis severity was measured using SOFA scores, while uric acid levels was measured by enzymatic method TBHBA with Architect C8200. All examinations were performed on the first and third day. Statistical analysis was performed with Spearman Correlation test using SPSS Results: A total of 16 (42.1%) men and 22 (57.9%) women were included in this study. There was a significant increase in SOFA scores from 4 (range 3–11) on the first day to 6 (range 2– 11) on the third day (p <0.001). There was also a significant increase in serum uric acid levels from 5.4 mg / dl to 6.2 mg / dl (p <0.01). There was a significant correlation of uric acid levels with SOFA scores on the first day (r = 0.4, p = 0.01) with moderate correlation strength, but there was no correlation between uric acid levels with SOFA scores on the third day (r = -0.04, p = 0.79). Conclusion: Serum uric acid levels have a significant correlation with SOFA score on the first day, and can be used as a predictor of sepsis severity

Uric Acid Levels as Predictor Of Sepsis Severity Related To Sofa Scores In Patients With Sepsis At ICU Adam Malik Hospital Medan