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Objectives: To study the association of genetic polymorphisms of coagulation factors with clinical and laboratory indicators in pregnant women with placental insufficiency with fetal growth retardation. Materials and methods: The study group included 250 pregnant women with placental insufficiency with fetal growth retardation (FGR). The control group consisted of 247 women without FGR. The participants were genotyped for four genetic markers of hereditary thrombophilia: fibrinogen (-455G/A FI), prothrombin (20210G/A FII), factor V Leiden (1691G/A FV), proconvertin (10976G/A FVII). Results: In the group of pregnant women with FGR, having genotypes -455GA FI and -455AA FI, a higher level of fibrinogen (4.7 g/l) is observed compared to women with the genotype -455GG FI (4.5 g/l, p=0.04). Conclusion: Thus, the study conducted on the relationship of polymorphic locus -455G/A FI with a higher level of fibrinogen in pregnant women with fetal growth retardation.

The Level of Fibrinogen and Gene Polymorphism in Pregnant Women with Placental Insufficiency