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Korystov Yu. N., V. A. Mosin, V. V. Shaposhnikova, M. Kh. Levitman, A. A. Kudryavtsev, E. B. Kruglyak, T. S. Sterlina, A. V.Viktorov, V. A. Drinyaev: A Comparative Study of Effects of Aversectin C, Abamectin and Ivermectin on Apoptosis of Rat Thymocytes Induced by Radiation and Dexamethasone. Acta Vet. Brno 1999, 68: 23-29. The effects of avermectins on radiation- and dexamethasone-induced apoptosis of rat thymocytes have been studied. In particular, the properties of abamectin (avermectin B1), ivermectin (22,23-dihydroavermectin B1, H2B1) and aversectin C were examined. Aversectin C is a mixture of eight naturally occurring avermectins of the following composition: B1 (42%), B2 (22%), A1 (13%) and A2 (23%). This mixture is currently widely used as active ingredient in veterinary antiparasitic formulations produced by Pharmbiomed Co. Apoptosis was estimated by membrane damage, nuclear pycnosis (or chromatin condensation), DNA fragmentation and percentage of cells with subdiploid DNA. It was shown that aversectin C inhibits thymocyte apoptosis induced by both agents. The IC50 dose was in the range of 0.1-0.3 µg/ml for aversectin C, whereas abamectin and ivermectin produced no effect up to 1 µg/ml. It is suggested that avermectins of the A series are responsible for the high anti-apoptotic activity exhibited by aversectin C. Thus, aversectin C is not only an effective antiparasitic drug but is also capable of exhibiting some other useful activities, e.g. a cytoprotective effect exerted on the mammalian immune cells. Avermectins, antiparasitic drugs, apoptosis, thymocytes, dexamethasone, gamma rays

A Comparative Study of the Effects of Aversectin C, Abamectin and Ivermectin on Apoptosis of Rat Thymocytes Induced by Radiation and Dexamethasone