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Acanthosis nigricans is characterized by the triad of papillomatosis, keratin hyperplasia and pigmentation in the skin. It develops in the nape of the neck, axilla and external genitalia in many cases. It was reported, however, that papilloma and hyperplastic epithelial lesions were observed also in the lip, oral cavity, esophagus and anus in some cases (Ueno, 1962). A patient with advanced gastric cancer associated with diffuse protruded lesions at the angles of the mouth, oral cavity and esophageal mucosa, which was categorized as malignant acanthosis nigricans without the typical skin pigmentation, is described below.

Case Report of an Advanced Gastric Cancer Associated with Diffused Protruded Lesions at the Angles of the Mouth, Oral Cavity and Esophagus.