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Cognitive dysfunction including Alzheimer’s disease (AD) and other neurodegenerative disorders are major health problem which are debilitating in nature. 1,2 The global prevalence of dementia in adults aged >60 years ranged from 5 to 7% with AD as the most common type followed by vascular dementia. 3,4 There are scarce and conflicting reports on the prevalence of dementia with far-reaching implications on the public health policies in the sub-Saharan Africa. 3,5,6 In Nigeria, incidence of dementia and Alzheimer’s in the Yoruba Africans is two to three times less, compared to the African Americans. 7 However, cases of dementia increased by 400% over the past 20 years such as from 1995-2015. 8 Research also revealed gender difference on the incidence of AD in which two thirds of patients with AD are women, raising the intriguing suggestions that there are biological mechanisms underlying the higher incidence of AD in women. 9 Neuroprotection refers to strategies and mechanisms able to defend the central nervous system against neuronal injury due to acute stroke or trauma including chronic neurodegenerative disorders. 10

tropical journal of natural product research

Neurobehavioural Enhancement in Scopolamine Hydrobromide-Induced Alzheimer Type Cognitive Dysfunction in Rats Following Administration of Ethanol Seed Extract of Telfairia occidentalis (Hook.f.) Cucurbitaceae