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Papaver somniferum, colloquially known as opium poppy, currently remains as the only commercial source of pharmaceutically important benzylisoquinoline alkaloids, of which include canadine. Canadine is an important naturally occurring alkaloid in current demand for pharmaceutical studies. Understanding the biosynthesis in plantae will help in increasing production of this alkaloid. In the present study, a comparative transcriptomic analysis was performed between gene expression data procured from the normal cultivar and a high canadine cultivar. Results indicated differential expression of key enzymes in the phthalideisoquinoline pathway leading to canadine biosynthesis. Specifically, it was found that transcription of genes encoding berberine bridge enzyme canadine synthase, and scoulerine 9-O-methyltransferase were significantly increased in the high canadine cultivar compared to the normal cultivar. These findings provide basis for further elucidating the coordinated transcriptional processes underlying canadine accumulation in P. somniferum cultivars.

In Silico Transcriptomic Analysis of Canadine Accumulation in Papaver Somniferum Cultivar