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Stress is the causative factor for various diseases and disorders faced by the majority of the diseased population. The leaves of Streblus asper (S. asper) are attributed to neuropharmacological properties as per literature. The S. asper hydroalcoholic extract as tested for antistress activity in animals. The study deals with the evaluation of S. asper hydroalcoholic extract for adaptogenic activity using cold immobilization stress. The S. asper hydroalcoholic extract (200 and 400 mg/kg) was administered to treatment groups 1 hour before stress methods for ten consecutive days. Induction of the stress procedure was repeated for ten days. Rats fasted overnight on 10th days, On 11th days the bloodwas collected from the retro-orbital vein for biochemical estimation under anaesthesia. Liver function pro iles (SGOT, SGPT, and ALP), lipid proiles (TC, TG, HDL, LDL, and VLDL), differential leukocyte count (neutrophils, eosinophils, lymphocyte, and monocyte), and organs weight (adrenal gland, spleen, liver, and kidney) were evaluation parameters of adaptogenic activity in the cold immobilization stress. The dose group 400 mg/kg p.o. of S. asper hydroalcoholic extract for adaptogenic activity in cold immobilization showed signi icant variation (P< 0.1) when is compared with the stress control group. Therefore, it was revealed that S. asper hydroalcoholic extract showed potential adaptogenic activity.

Experimental evaluation of Streblus asper hydroalcoholic extract for antistress activity