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Schef lera umbellifera (Sond.) Baill. is an evergreen tree widely used as traditional medicine throughout its distributional range in southern Africa. Schef lera umbellifera is indigenous to Eswatini, Malawi, Mozambique, South Africa and Zimbabwe. This study was aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of S. umbellifera. Documented information on medicinal uses, phytochemical and pharmacological properties of S. umbellifera was collected from several online sources such as Scopus, Google Scholar, PubMed, Francis and Taylor and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scienti ic publications obtained from the University library. This study revealed that the bark, leaf and root decoction or infusion of S. umbellifera are mainly used as diuretic, laxative, colic and protective charm, and traditional medicine for stomach ulcers, weaning infants, insanity, in lammation, rheumatism and malaria. Phytochemical compounds identi ied from the species include 3-hydroxy-20(29)-lupen-28ol, 7-hydroxy-6-methoxycoumarin, betulin, ent-kaur-16-en-19-oic acid and oleanolic acid. Pharmacological research revealed that S. umbellifera extracts and compounds isolated from the species have antibacterial, anti-HIV, antiin lammatory, antimalarial, antiprotozoal, larvicidal and cytotoxicity activities. Schef lera umbellifera should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.

A synthesis and review of medicinal uses, phytochemistry and pharmacological properties of Schef৒lera umbellifera (Sond.) Baill. (Ar aliaceae )