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Chronic disorders or diseases like hypertension, diabetes-mellitus, cancer, heart failure, pulmonary hypertension are becoming more prevalent nowadays even at a younger age. Various methods have been introduced to determine several diseases out ofwhich the concept ofmeasurement of endothelins and matrix metalloproteinases and the usage of endothelin receptor antagonist as a way of treatment either singly or combinedly with other drugs has achieved more importance. By the usage of serummatrix metalloproteinases (MMPs) and endothelinswe can determine the peoplewho are at risk of developing hypertension, type2 diabetes, heart failure, atherosclerosis, cancer, pulmonary hypertension and can also assess the range of complications that are going to occur in the individual. These elevated levels cause remodelling after a period of time. Hence, the detection is done through a method in which few factors like endothelins and MMPs of our body are measured through a blood sample, maximum bene its can be obtained in individuals who have a significant family history of developing hypertension and other conditions In this reviewwehavediscussed about various effects of endothelins in different conditions, and also to know if these conditions can be improved or not by using endothelin receptor antagonists.

international journal of research in pharmaceutical sciences

Effects of endothelins and matrix metalloproteinases in various pathological disorders and their antagonism at a better treatment modality in modern medicine