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This experiment shares the method development and analytical validation of an original, accurate and correct UV-Visible Spectrophotometric methods for the ixed dose assessment of Ramipril and Amlodipine besylate. The working solutions of Telmisartan and Ramipril were scanned at 240 nanometer and 210nanometer respectively. The regression strength of Amlodipine besylate and Ramipril over its absorbances take place as y=0.4291x0.0084 and y=0.0399x-0.310 respectively with a correlation coef icient (r) of 0.9998 for Amlodipine besylate and 0.9993 for Ramipril. The intra-day precision in addition inter-day precision for Amlodipine besylate and its % RSDwere obtained as 0.08% and 0.25% respectively. The intra-day precision in addition interday precision for Ramipril and% RSD were obtained as 0.16% and 0.24% respectively. The precise amount of tablet formulation were added which holds Alkaline (0.1 N Sodium hydroxide), Acidic (0.1 N Hydrochloric acid) re lux for 3 hours, 3% Oxydol at 50oC, heat (60oC), humidity (75 percentage Relative humidity) for 24 hr. and after the particular time diluted to distilled water, separated using Filter paper. From this stock solution, 5 mL section of the iltrate was pipetted out and further thinned with distilled water in a 100 mL standard lask (10μg/mL). The standard stock solution of two drugswere prepared and compared against a label claim.

Method Development and Validation of simultaneous estimation for Ramipril and Amlodipine besylate by UV- VISIBLE Spectrophotometric method