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Nefopam is a non-opioid, centrally acting, non-steroidal analgesic drug. It is used to treat mild to moderate painful conditions. Although developed about ive decades ago, its use has gained resurgence in recent years. This studywas designed to investigate the effects of different analgesic doses of nefopam on the liver and kidneys of mice. Forty albinomice were divided into four groups of 10 mice for each group. Group 1, 2 &3 received a daily intraperitoneal injection of Nefopam at 10, 20, and 30 mg/kg doses, respectively. The fourth group (control group) received injections of normal saline. After twoweeks of treatment, the animals were weighed and sacri iced, and then blood was collected for liver enzymes analysis and renal function test as well as histological assessment. The results revealed that the bodyweight increase ratio was signi icantly lower in group 3 (P-value <0.01). All tested liver enzymes i.e., ALT, AST, and ALP levels showed a highly signi icant (P-value <0.01) change among the tested groups. AlthoughALT remainedwithin normal limits in the irst two groups andnormal group, in group3 (30mg/kg), its level exceeded thenormal value. Liver enzyme changes re lected and supported the histopathological indings in the liver tissue. Group 2 & 3 showed varying degrees of hepatotoxicity, ranging from granulomatous lymphocytic in iltration to micro-vesicular steatosis and apoptotic pictures. Both kidney function test and histopathological examination, on the other hand, illustrated insigni icant effect (P-value >0.05) ofNefopamon the kidneys. Nefopam iswell tolerable by the liver at low analgesic doses butmayhavedetrimental effects at higher analgesic doses and prolonged duration of intake.

Nefopam induced dose-related changes in renal and hepatic functions