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Brecher et Waxler (1949) and Mayer et Zighera (1954) reported the presentation of a remarkable obesity in mice subjected to the injection of LD5, dose of goldthioglucose, but none of these authors have referred to the genesis of this symptom. Likewise, there have been no literatures which elucidate in detail the pharmacological effects of LD-, of goldthioglucose on individuals as well as its effects on histological changes of visceral organs and tissues. Throughout the present study, the authors succeeded in realizing that LD50 of goldthioglucose would exert a specific effect on a certain localized portion of the hypothalamus of mice to cause conspicuous histological changes in them. The authors believe that such changes as detected in hypothalamus give a clue to the clarification of the genesis of goldthioglucose obesity. Therefore, this paper will deal with the results obtained from the present study.

On histological changes of hypothalamus in mice caused by administration of goldthioglucose