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Objective. To evaluate the effectiveness of brain evoked potentials for the objectivization of early cognitive disorders (CD) induced by cerebral and regional hypoperfusion. Materials and methods. The influence of hypoperfusion in vertebrobasilar territory (VBT) on characteristics of cognitive functions in 52 patients with chronic brain ischemia was studied. The following methods were used: clinico-neurological, MRI, SPECT, duplex ultrasound scanning (DUS), EEG, and brain evoked potentials (EP). Results. The patients were split into two groups by DUS scan findings: 1 – those having structural lesions in vertebral arteries (VA), and haemodynamically significant disorders in VBT and 2 – those having none. The examination of patients of the 1 st group showed the following findings: high frequency of blood flow velocity decrease in VA; the tendency of decreasing in volumetric cerebral blood flow in brain segments and hemispheres according to SPECT data; prevalence of ataxia, coordination and long tract signs; high frequency of early CD in the domains of attention and memory; EP index changes. The patients with blood flow decompensation in VBT (according to DUS findings) showed changes in brainstem auditory EP parameters (BAEP): increase of III, IV, V latency peaks and III-V interpeak interval. According to the cognitive EP (CEP) study, the patients of the 1 st group consistently demonstrated higher frequency of N2 peak amplitude decrease, and P300 peak latency increase. Conclusions. Based on DUS scan findings, it is clinically appropriate to distinguish a group of patients with structural and haemodynamically significant disorders in VA. The deviations from the normal indices of CEP and BAEP correlate with CD occurring as a result of cerebral and regional hypoperfusion in VBT.

Evoked brain potentials in patients with chronic vertebrobasilar ischaemia depending on the features of cerebral and regional perfusion