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5 BACKGROUND  7 Easy-to-Use ACP Tools  8 Aims  10 Significance 10 Innovation  11 PARTICIPATION OF PATIENTS AND OTHER STAKEHOLDERS  12 Description of the Stakeholder Advisory Board  12 Impact of the Stakeholder Advisory Board  12 Table 1. Notable Impacts of Engaging Diverse Stakeholders  14 METHODS  16 Study Overview  16 Study Design  17 Figure 1. PREPARE study flow diagram  18 Study Setting  19 Participants: Forming the Study Cohort 19 Table 2. Inclusion and Exclusion Criteria of Participants  22 Interventions and Comparators  27 Figure 2. PREPARE welcome webpage with the 5 steps of the program in English and Spanish  29 Figure 3. Easy-to-read advance directive in English and Spanish  31 Study Outcomes  33 Table 3. Study Outcome Measures  39 Time Frame for the Study  43 Data Collection, Sources, and Retention Strategies  43 Analytic and Statistical Approaches  45 Table 4. Cumulative Loss to Follow-up at Each Time Point  50 Changes to the Original Protocol  51 Table 5. Summary of Changes to the Original Protocol Listed by Topic  51 Table 6. Summary of Changes to the Statistical Analysis Plan  55 RESULTS  56

Preparing Spanish-speaking Older Adults for Advance Care Planning and Medical Decision-Making—The PREPARE Trial