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Endophytes encompass the widespread taxa of yet under-explored endosymbionts that are believed to bestow, to the benefit of their host plants bioactive compounds enabling the later to withstand biotic and/ or abiotic stresses. Some of these molecules are pharmacologically valuable compounds. Herein, we do report the isolation of a newly identified endophytic strain of Aspergillus niger named karmali from roots and twigs of Punica granatum. Aspergillus niger strain karmali has been used in a solid-state fermentation on rice medium enriched with peptone and artificial seawater. The polar phase of the culture extract was fractionated using Dry Column Vacuum Chromatography (DCVC). The cancer treatment potential of the major fraction of the endophytic compounds was determined in vitro as its cytotoxicity against ovarian cancer cell line SKOV-3 and lung cancer cell line A549. As a result of cell culture experiments, IC50 values were determined to be 1.08 μg / ml for SKOV3 cells and 11.7 μg / ml for A549 cells at 24 hours. The cancer treatment potential of the purified endophytic compound was found to be more active on SKOV-3 cell. Biocompatibility tests were performed in order to determine its effectiveness in vivo conditions, and it was determined to be biocompatible.

sdrp journal of plant science

Cytotoxic potentials of the culture extract of the endophytic Aspergillus niger strain karmalı isolated from Punica granatum against SKOV3 and A549 cancer cell lines