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To investigate the genetic effect of gestational diabetes mellitus GDM by study expression of IRS1 gene was measured in women with GDM is characterized by high level of blood glucose, especially during 3 rd trimester of the pregnancy period. The blood samples taken from one hundred twenty: 60 healthy pregnant and 60 pregnant with GDM in 3 rd trimester of pregnancy, levels of fasting blood glucose (FBG) and HbA1c% was used to diagnose GDM. In addition to lipid profile (cholesterol, triglyceride, HDL, LDL, and VLDL). Molecular study was consisted of RNA extraction and qRTPCR for IRS1gene expression determination. The fasting blood glucose mg/dl and HbA1c% level was highly significantly increase (P<0.01) between patients and control (healthy women) in 3 rd trimester stage in addition lipid profile )serum cholesterol, serum triglyceride, LDL and VLDL( (mg/dl) but level of HDL (mg/dl) were decreased highly significantly (P<0.01) between patients and control. The result were showed significant increasing of IRS1 expression gene in control (1.00 ± 0.00) while decrease in patients (0.147 ± 0.02). It concluded that the low expression of IRS1 gene was connected with gestational diabetes mellitus comparison in control Iraqi women in third trimester of pregnancy.

Expression of IRS1 Gene in Pregnant Women with Gestational Diabetes Mellitus, in The Third Trimester