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To evaluate the effect of different luteal phase protocols on the success of pregnancy in patients undergoing Intrauterine Insemination (IUI), 80 cycles which assigned into 4 groups (20 cycles each) were included in the study. Luteal phase support was provided by vaginal progesterone gel, vaginal micronized progesterone, intramuscular progesterone and oral progesterone in the respective groups. Groups were randomized according to the luteal support pattern. Luteal phase support was commenced on the day of IUI. Beta Human Chorionic Gonadotropine (ßhCG) was measured on the day 14 after IUI. In patients with positive test result, luteal phase support was maintained until gestational week 8. Pregnancy including 16 clinical pregnancies and one biochemical pregnancy were achieved in 17 in patients in whom Ovulation Induction (OI) and IUI were performed. In patients with clinical pregnancies, pregnancy resulted in miscarriage in 2 patients and live birth in 3 patients (twin in one patient) while there was ongoing pregnancy in 11 patients including 10 single and one triplet pregnancies. There was no significant difference in pregnancy rate (p=0.373) and ongoing pregnancy rate (p=0.18) among groups. In patients underwent OI by gonadotropins and IUI, luteal phase support with oral dydrogesterone, vaginal micronized progesterone, vaginal progesterone gel and intramuscular hydroxyprogesterone have similar effects on clinical pregnancy and live birth. If the absence of difference was confirmed, dydrogesterone should be preferred due to lower cost and better patient compliance. However, the limitation of this study is that only 16 clinical pregnancies are obtained when 4 groups are compared. In addition, luteal support therapy should be initiated after ovulation.

hsoa journal of reproductive medicine gynaecology and obstetrics

The Investigation Effects of Different Luteal Support Protocols on the Patients who Applied Ovulation Induction with Gonadotropines and Intrauterin Insemination