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Autophagy appears to have differing roles in varied types of breast cancer cells. Autophagy plays a complex role in tumor initiation and progression. MicroRNAs (miRNAs) are non-coding small RNAs that play an important role in the post-transcriptional regulation of gene expression. Recent studies indicated that miRNAs are also mediators in breast cancer progression. A thorough understanding of the molecular mechanisms controlling autophagy in homeostasis may eventually allow for the manipulation of the process specific target of breast cancer migration and invasion in therapeutic applications. Results demonstrate how a breast cancer cell model can be used to study the relationship between miRNA-200c and miRNA-205, and autophagy. Confocal microscopy was utilized to examine changes in autophagic flux. This study revealed that miRNA-200c and miRNA-205 were altered significantly in autophagic flux in comparison with the FDA-approved drug (chloroquine-CQ) in the BT549 and MCF7 breast cancer cell types.

A Pilot Study-Comparison between miRNA-200c and miR-205 in Breast Cancer Cells