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Study background: Canine Ehrlichiosis is an infectious disease caused by bacteria from the Anaplasmataceae family, infecting monocytes, platelets, and polymorph nuclear cells. The disease can affect dogs at any age and causes a great variety of clinical signs and hematological changes. Treatment for canine Ehrlichiosis includes oral doxycycline for at least 28 days to several months, depending on each dog individual responses to the treatment. Prolonged treatments appear to be related to adverse collateral effects at the gastrointestinal level. We designed this study for evaluating the frequency of gastrointestinal tract injuries and clinical signs before and after treatment with oral doxycycline of dogs suffering from canine Ehrlichiosis. Methods: In a descriptive longitudinal study, a group of working dogs that rested seropositive for canine Ehrlichiosis (n=19) received oral doxycycline (10mg/kg/24h/28days). Dogs were evaluated by clinical exam, endoscopic gastro-duodenoscopy performed under general anesthesia, a sampling of a biopsy and it’s processing of histopathological evaluation and detection of Helicobacter spp., and clinical follow up during treatment and at 30 days after treatment was finished. Results: Diarrhea was the most frequent clinical sign, showing a positive correlation between the age of the dog (P<0.05). The most common histopathological finding was edema of the gastric and duodenal mucosa, which tended to increase at day 30 after treatment finished (P=0.12). The presence of Helicobacter spp., tended to increase in patients after treatment finished (P=0.12). Conclusion: No significant changes of gastric mucosa were evidenced after oral treatment with doxycycline, whereas the presence of Helicobacter spp., in gastric mucosa trend to reduce at day 30 after treatment. Finally, the significant correlation between doxycycline treatment and age of patient suggest an adverse outcome of this treatment schedule on older patients.

hsoa journal of animal research and veterinary science

The Incidence of Histopathological Lesions in Gastric Mucosa and Gastrointestinal Signs in Dogs Suffering from Canine Ehrlichiosis Undergoing Treatment with Doxycycline: A Descriptive Longitudinal Study