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The present study was conducted to analyse the predisposed conditions developing multiple organ failure (MOF) in sepsis. Primarily a sepsis model was established to confirm the hypothesis that DIC predisposes MOP.Fecal suspension was injected fined into ligated biliary tree in Japan male rabbits. After the insult, serial blood sampling disclosed the onset of DIC with decrease of pletelet counts, leukocyte counts, and fibrinogen concentrations and with prolongation of PT and APTT values. Simultaneously serum bilirubin and creatinine levels elevated. Plasma endotoxin concentrations also gradually elevated. In the histological examinations of the liver, multiple focal necrosis and neutrophil infiltration into sinusoid were observed.Heparin (50u/kg/h) and MD 805 (a specific trombin inhibitor; 300μg/kg/h) treatments significantly prevented decrease of platelet counts and elevation of bilirubin and creatinine levels in sepsis. The histological changes of the liver were minimized by both heparin and MD 805. Thus, these results indicate that hypercoagulable state undoubtedly contributes to the progression of MOF, which can be controlled by anticoagulant therapy.

Studies on a septic rabbit model which develops MOF associated with DIC; Effects of anticoagulant therapy.