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Age-related increase has been observed in thrombotic disease. A change in fibrinolysis activity may play an important part in the pathogenesis of thrombotic disease. Therefore, this study was designed to investigate age-related changes in the plasma levels of fibrinolysis factors including plasminogen, α2PI and t-PA antigen as well as the plasma PA activity.The plasma level of α2PI was negatively correlated with age in both sexes. This age-related decline was more obvious in male (r=-0.515) than female (r=-0.268). The plasma plasminogen level and PA activity did not differ depending on age. The t-PA antigen concentration showed a positive correlation with age in female (r=0.650) and in male (r=0.463).

Age-related change of the concentrations of plasminogen, .ALPHA.2PI and t-PA antigen, and PA activity in plasma.