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The regulation mechanism of fibrinogen synthesis is unclear. Thrombin, free fatty acids, ACTH, FgDP were reported as stimulators of fibrinogen synthesis. This experiment was done to examine the existence of humoral stimulating factors in DIC serum. In dogs, after continuous infusion of tissue thromboplastin (Lyoplastin) 12. 5 mg/kg for 3 hrs, platelet counts, antiplasmin, fibrinogen decreased to nearly 30%, 35%, 0% and FPA, FDP increased to 10 ng/ml, 660pg/ml respectively. After cessation of administration of Lyoplastin, fibrinogen increased rapidly and returned to the value of preinjection at 3 days after. So, these dogs were used as acute DIC model. Serum of these dogs was sampled at this recovery phase of fibrinogen (6, 24, 48, 72 hrs) and treated with bentonite to absorb FDP. 3 ml of these sera were administered to rabbits and 755e-methionine (755e-M) 20 pCi was injected 5 hrs after. The effects of DIC dog serum on fibrinogen synthesis in rabbits were evaluated by calculating the incorporated 75Se-M into newly synthesized fibrinogen and by circulating fibrinogen concentration. Although the statistical significance was not obtained, the existence of humoral stimulating factors on fibrinogen synthesis in rabbits was suggested by injectien of DIC induced dog serum at 72 hrs after Lyoplastin infusion.

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Evaluation of the humoral factors on fibrinogen synthesis: An experimental study of fibrinogen synthesis in rabbits after injection of DIC induced dog serum