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Deterioration of microcirculation is regarded as the most important factor in the pathogenesis of diabetic microangiopathy. In order to understand to what extent the red cell rheology could contribute to the cause of the microangiopathy, this study was conducted to investigate the abnormalities of red cells in diabetes mellitus, especially changes in the def ormability and osmotic resistance, observing the hemoglobin Al (HbAI) concentration of red cells. HbAI concentration is considered to reflect better whether blood glucose is well or poorly controlled during last one to two months. Deformability was examined by a negative pressure filtration method, newly deviced system using polycarbonate sieves. For the examination of osmotic resistance of red cells we used a coil planet centrifuge and took the hemolytic end point as an index of hemolysis. HbAI of red cells was analysed by a modification of the method of Trivelli et al. Twenty four healthy subjects and fifty one diabetic patients (most of them having maturity onset diabetes) were investigated for this study. Decreased def ormability and increased osmotic resistance were observed in red cells from diabetic patients. These findings suggested that rheological properties of the membrane or content of red cells in diabetics would be different from those in healthy subjects. Higher concentrations of HbAI were also observed in diabetics whose blood glucose was poorly controlled, showing the tendency of positive

Red cell rheology in diabetics, with special reference of the pathogenesis of microangiopathy