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Thrombolytic therapy with urokinase (UK) requires large quantities of UK to achieve the desired effect. In order to find a means of reducing the necessary quantity of UK, the effect of concomitant UK and low-molecular-weight dextran sulphate (DS) (3, 900) administration was examined in the rabbit. The fibrinolytic curves after DS administration moved to left and upward when compared to that of before DS administration, suggesting the increase of the sensitivity to UK. Such increase of the sensitivity to UK was reconfirmed in human.The fibrinolytic activity in the euglobulin fraction after the concomitant administration of UK and DS was markedly enhanced and sustained for long periods after the completion of UK infusion, indicating that the inactivation rate constant of UK was smaller during the UK infusion.These results indicate that concomitant administration of UK and DS may be helpful for reducing the necessary quantity of UK for thrombolytic therapy.

Enhanced fibrinolytic activity by concomitant administration of urokinase and dextran sulphate