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Sarcoplasmic reticulum Ca 2+ ATPases (SERCA) enzymes are essential for intracellular Ca 2+ homeostasis. SERCA genes (ATP2A1-3) encode for different functional isoforms of the protein, whose expression or function is altered in several types of cancer, such as gastric and oral, as well as colon, breast, lung, thyroid, liver, and prostate cancer, among others. However, the role played by SERCA pumps in carcinogenesis is unknown.

Sarcoplasmic reticulum Ca2+ ATPases genes differential expression in breast cancer cells