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Delayed graft function (DGF), defined as the need for renal replacement therapy during the first 7 days post-transplant or serum creatinine not decreasing < 10 % for 3 consecutive days,1 is one of the most common complications of kidney transplantation;2 it originates due to the ischemia-reperfusion injury that occurs after kidney transplantation and has been shown to be a risk factor for acute rejection and renal graft acute nephropathy that may favor its loss within the first year.3-6 Different therapeutic approaches to prevent DGF have been explored; however, successful options in animal models have not been reproduced in humans3,7 owing to late identification of this injury,3,8-10 since current biomarkers for its diagnosis (which include serum creatinine and urinary output) are poorly sensitive for its prediction.11-14 There is a current need for more sensitive and specific markers that enable DGF and subclinical kidney injury early diagnosis,15 in order for therapeutic interventions that increase renal graft survival to be established.3,16 Recent studies suggest that urinary neutrophil gelatinase-associated lipocalin (uNGAL) could be superior to serum creatinine for DGF early detection, since its elevation can occur within the first 12 hours after kidney transplantation in patients with subclinical dysfunction.3,5,7,16-26 However, there are only few studies that have assessed uNGAL usefulness as a long-term predictor of renal graft function, and it is not clear whether its values can predict dysfunction.2,18,21,27,28 At Hospital Pablo Tobón Uribe, in Antioquía, Medellin, Colombia, deceased donor transplants, where the Abstract

Urinary neutrophil gelatinase-associated lipocalin as graft dysfunction predictor at one year of kidney transplantation