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Analysis of Codon 972 (Gly → Arg) Polymorphism in IRS-1 Gene in Type 2 Diabetic Population Polymorphism of Insulin Receptor Substrate-1, especially the GGG→AGG (Gly-Arg) substitution at codon 972, is one of the major factors leading to the development of type 2 diabetes mellitus. This defect in IRS-1 causes insulin resistance along with many other consequences. It generally impairs insulin signalling via the phosphadylinositol-3 (PI3)-Kinase pathway. In this study, the heterozygous Gly→Arg substitution at codon 972 of the IRS-1 gene was found in 2 of the 43 control Indian subjects, which is higher than normal when compared with the other population. The prevalence of the codon 972 GGG→AGG substitutions was found to be around 4.6%, which may be due to a predisposition factor. In diabetic subjects, on the other hand, 5 out of 43 showed substitution at codon 972, with a percent prevalence of 14%, establishing the role of the polymorphism of IRS-1 codon in the prevalence of diabetes mellitus. Analiza Polimorfizma u 972. Kodonu (Gly→Arg) u Genu IRS-1 Kod Obolelih od Dijabetesa Tipa 2 Polimorfizam supstrata insulinskog receptora 1, posebno supstitucija GGG→AGG (glicinarginin) u 972. kodonu, jedan je od glavnih faktora koji dovode do razvoja dijabetes melitusa tipa 2. Ovaj defekt u IRS-1 izaziva insulinsku rezistenciju kao i brojne druge posledice. U najvećem broju slučajeva oštećuje insulinsku signalizaciju preko putanje fosfadilinositol-3 (PI3)-kinaza. U ovoj studiji, heterozigotna supstitucija glicin arginin u 972. kodonu gena IRS-1 pronađena je kod 2 od 43 kontrolna subjekta indijske nacionalnosti, što je više od normalnog nivoa u poređenju s drugom populacijom. Utvrđeno je da je prevalenca supstitucija GGG→AGG u 972. kodonu oko 4,6%, što može biti posledica faktora predispozicije. S druge strane, 5 od 43 subjekata sa dijabetesom imalo je supstituciju u 972. kodonu, uz prevalencu od 14%, što ukazuje na to da polimorfizam kodona u IRS-1 ima ulogu u prevalenciji dijabetes melitusa.