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Heart failure (HF) is a common condition, especially in older patients. Considering the increase of life expectancy the total number of HF patients is expected to grow in the future, which makes HF an important focus of research. New high-throughput techniques, such as the “omics” (genomics, transcriptomics, metabolomics) have brought new insight into disease pathophysiology, facilitating the discovery of an impressive number of candidate biomarkers. In this review we consider different perspectives on the evaluation and clinical potential of biomarkers in heart failure as their usefulness in clinical settings is constantly being evaluated in order to bring them closer to the point-of-care. In addition, we examine recent advances in the methods of detection and quantification of biomarkers Rezumat Insuficienţa cardiacă este o afecţiune cu o prevalentă ridicată, în special în rândul pacienţilor vârstnici. Pe viitor, se preconizează creşterea numărului de pacienţi cu insuficienţă cardiacă, luând în considerare creşterea speranţei de viaţă, ceea ce sporeşte interesul ştiinţific pentru această patologie. Noile tehnologii „omice” cum ar fi genomica, proteomica sau metabolomica au contribuit la elucidarea fiziopatologiei insuficienţei cardiace prin furnizarea unui număr impresionant de potenţiali biomarkeri. In acest review vom prezenta diferiţii biomarkeri candidaţi şi uzuali pentru insuficienţa cardiacă şi utilitatea lor clinică, precum şi progresele făcute pentru creşterea sensibilităţii, selectivităţii şi reproductibilităţii metodelor lor de detecţie şi cuantificare

Advances in the detection and quantification of candidate and established biomarkers in heart failure