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Background: The subjects with impaired glucose tolerance have an increased risk for future type 2 diabetes (T2DM); however, a significant number of individuals who develop T2DM have normal glucose tolerance (NGT) at baseline. The study aims to compare glycated hemoglobin (HbA1C) and homeostasis model assessment (HOMA-IR) levels to 30, 60 and 90-min glucose levels in subjects with NGT. Methods: A 75-g oral glucose tolerance test (OGTT) at 0, 30, 60, 90 and 120-min was performed in 1118 subjects without known T2DM. Blood samples were also drawn for fasting insulin and HbA1C levels. Results: Forty percent of the subjects with NGT had increased post-challenge values above the determined optimal glucose levels (10.2, 10.3 and 8.9 mmol/L at 30, 60 and 90-min, respectively). Compared to the subjects with NGT whose glucose levels were below the determined optimal values at 30, 60 and 90-min, we found significantly elevated HbA1C and HOMA-IR levels in the subjects with NGT whose glucose levels were above the determined optimal values (p<0.001). Conclusions: We conclude that the subjects with NGT have different HbA1C and HOMA-IR levels considering glucose levels measured earlier than at 2-h during OGTT. Further well-designed prospective studies are needed to define the significance of 30-min, 60-min and 90-min glucose levels in the prediction of disease in subjects with T2DM. Kratak sadržaj Uvod: Osobe sa poremećajem tolerancije glukoze izložene su povećanom riziku za dobijanje dijabetesa tipa 2 (T2DM), međutim, značajan broj pojedinaca koji dobiju T2DM ima u početku normalnu toleranciju glukoze (NGT). Cilj ove studije bio je da se uporede nivoi glikoliziranog hemoglobina (HbA1C) i modela homeostaze (HOMA-IR) sa nivoima glu- koze posle 30, 60 i 90 minuta kod osoba sa NGT. Metode: Test oralne tolerancije glukcee (OGTT) sa 75 g glukoze urađen je u 0, 30, 60, 90. i 120. minutu kod 1118 subjekata bez T2DM. Uzorci krvi su takođe uzeti radi mere- nja nivoa insulina i HbA1C. Rezultati: Četrdeset odsto subjekata sa NGT imalo je povišene nivoe posle testa u odnosu na utvrđene optimalne nivoe glukoze (10,2, 10,3 i 8,9 mmol/L posle 30, 60 i 90 minuta). U poređenju sa subjektima sa NGT kod kojih su posle 30, 60 i 90 minuta nivoi glukoze bili ispod utvrđenih optimalnih vrednosti, otkrili smo značajno povišene nivoe HhA1C i HOMA-IR kod subjekata sa NGT čiji su nivoi glukoze bili iznad utvrđenih optimalnih vrednosti (p< 0,001). Zaključak: Zaključujemo da subjekti sa NGT imaju različite nivoe HbA1C i HOMA-IR s obzirom na nivoe glukoze izmerene pre drugog sata tokom testa oralne tolerancije glukoze. Potrebne su nove, pažljivo osmišljene, prospektivne studije kako bi se definisao značaj nivoa glukoze posle 30, 60 i 90 minuta u predikciji bolesti kod osoba sa T2DM.

journal of medical biochemistry

The Comparison of Glycated Hemoglobin and Homeostasis Model Assessment Values to 30, 60 and 90-Min Glucose Levels During OGTT in Subjects with Normal Glucose Tolerance