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Summary Background: Oxidative stress is thought to be a major contributor to complications during pregnancy, for example preeclampsia. However, reports regarding prooxidant-antioxidant balance in uncomplicated pregnancy are inconsistent. In this study, we aimed to compare the levels of oxidative stress in non-pregnant women with apparently normal pregnant women during the first trimester and at delivery. Methods: An assay for the determination of prooxidant-antioxidant balance (PAB) was used in this study, in which the prooxidant burden and the antioxidant capacity were measured simultaneously in a single assay. The levels of oxidative stress were determined in 85 non-pregnant and 64 primigravid pregnant women. Results: Demographic data and biochemical indices did not differ significantly between the groups. Differences between PAB values were significant based on one-way ANOVA analysis (P<0.001). Using a post hoc test, we observed a statistically significant increase in PAB values during the first trimester and last trimester (P<0.001). Conclusions: Normal pregnancy is associated with a change in the measure of redox status, as assessed by the PAB assay. Kratak sadržaj Uvod: Veruje se da oksidativni stres u velikoj meri doprinosi komplikacijama u toku trudnoće, kao što je na primer preek- lampsija. Međutim, izveštaji o ravnoteži između prooksidanasa i antioksidanasa u trudnoći bez komplikacija se razlikuju. U ovoj studiji, cilj nam je bio da uporedimo nivoe oksidativnog stresa kod žena koje nisu trudne sa ženama u naizgled normal- noj trudnoći tokom prvog tromesečja i na porođaju. Metode: U studiji je za određivanje ravnoteže prooksidansi/ antioksidansi (PAB) korišćen test u kom se istovremeno mere prooksidantni balast i antioksidantni kapacitet, u jednom testu. Nivoi oksidativnog stresa određeni su kod 85 žena koje nisu bile trudne i 64 trudnice u prvoj trudnoći. Rezultati: Demografski podaci i biohemijski indeksi nisu se značajno razlikovali između grupa. Analiza ANOVA ukazala je na značajne razlike između vrednosti PAB (P<0,001). Pomoću post hoc testa uočili smo statistički značajan po- rast vrednosti PAB u toku prvog i poslednjeg tromesečja (P<0,001). Zaključak: Normalna trudnoća povezana je s promenom u meri redoks statusa, utvrđenoj na osnovu PAB testa.

Determination of Prooxidant–Antioxidant Balance during Uncomplicated Pregnancy Using a Rapid Assay